Jaundice in Newborn

When you're dealing with a tiny human who hasn't quite mastered the art of eating, a high chair that's a breeze to clean is an invaluable asset. When you're shopping, keep in mind that the best easy-to-clean high chairs are made with materials that can be wiped with a damp cloth, like wood, vinyl, and leatherette, and they have detachable trays that can be put in the dishwasher. Plus, many of them have removable seat pads and straps that can be machine washed. As you're shopping, consider these things: Removable parts: A high chair that has removable parts is crucial to the cleaning process, making it significantly easier to reach tight corners where crumbs might be hiding. Plus, a detachable, dishwasher-safe tray will speed up the amount of time you spend on post-meal cleanup. Ease of wiping: While many seat pads and straps are detachable and machine-washable, it's worth looking for materials that are easy to wipe clean in between laundry days like leatherette

For those of us treating patients with liver disease throughout the pandemic, we have anticipated evidence-based guidance regarding the contribution of specific liver disease phenotypes and immune suppression/transplantation on COVID-19 susceptibility and outcome. Now, data is emerging to help answer some of the major questions surrounding COVID-19 and the liver. Does the Virus Itself Cause Liver Disease? The answer to this question is still a bit unclear. Multiple early reports [1,2,3,4,5,6,7,8,9,10,11] stated that hospitalized patients with SARS-CoV-2 infection frequently had elevated values on liver biochemistry tests. For example, the reported incidence of elevated serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) levels ranged from 14% to 83%, yet the magnitude of enzyme elevation was generally reported to be mild and normalized as COVID-19 symptoms improved. Unsurprisingly, patients with severe liver injury (defined as

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Transcutaneous bilirubin measurements are convenient, but how much accuracy are you willing to give up for convenience? Source: Olusanya BO, Imosemi DO, and Emokpae AA. Differences between transcutaneous and serum bilirubin measurements in black African neonate. Pediatrics. 2016;138(3):e20160907 ; doi:10.1542/peds.2016-0907. See AAP Grand Rounds commentary by Dr. Jonathan Mintzer (subscription required). The authors of this study, performed on African newborns in Nigeria, found that transcutaneous bilirubin (TcB) measurements, compared to total serum bilirubin (TSB) concentrations, often overestimated bilirubin levels. It was pretty impressive: in the population of over 1500 infants and over 2000 measurements, TcB overshot by at least 2 mg/dL in about two-thirds of the babies, and by at least 4 mg/dL in about one quarter. That's a lot of unnecessary treatments, if therapy were instituted based on TcB a

[unable to retrieve full-text content] Elevated Bilirubin: Symptoms, Causes & Treatment | Hyperbilirubinemia    Healthgrades

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Abstract Neonatal jaundice occurs in >80% of newborns in the first week of life owing to physiological hyperbilirubinemia. Severe hyperbilirubinemia could cause brain damage owing to its neurotoxicity, a state commonly known as kernicterus. Therefore, periodic bilirubin monitoring is essential to identify infants at-risk and to initiate treatment including phototherapy. However, devices for continuous measurements of bilirubin have not been developed yet. Here, we established a wearable transcutaneous bilirubinometer that also has oxygen saturation (SpO 2 ) and heart rate (HR) sensing functionalities. Clinical experiments with neonates demonstrated the possibility of simultaneous detection of bilirubin, SpO 2 , and HR. Moreover, our device could consistently measure bilirubin during phototherapy. These results demonstrate the potential for development of a combined treatment approach with an automatic link via the wearable bilirubinometer and phototherapy device for optimization