Jaundice in Newborn

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Background Jaundice is one of the most common medical complications causing neonatal readmission during the neonatal period. 1,2 It is a preventable and treatable clinical complication, but letting untreated can end up in neonatal mortality. The occurrence of jaundice among neonates during the first week of their life is 60% 3,4 among term and 80% 4,5 among preterm newborns. Neonatal jaundice is the most common cause of readmission for neonates during their neonatal period. 6 It is accountable for 70% and 10% of neonatal morbidity and mortality, respectively, worldwide. 5,7 As an earlier report indicated that, out of the 130 million babies born per year, approximately 4 million died within their neonatal period. 8 Of the total neonatal mortality secondary to jaundice complications, about 75% of neonatal mortality occurred in South Asia and sub-Saharan Africa. 9 In Ethiopia, neonatal mortality and morbidity are among the highest in the world, on which 6 more than one-third of

Seeing your baby have yellowish eyes and skin can easily send parents into panic mode, especially if you've never seen it before.  Advertising Policy Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy This yellow discoloration in a newborn is called jaundice, and it's a common issue, says pediatric gastroenterologist Kadakkal Radhakrishnan, MD. Jaundice is due to an elevated level of yellowish pigment in the blood called bilirubin that forms when the baby's body breaks down excess red blood cells. Bilirubin is carried through the blood to the liver, where it's tagged to a chemical and excreted into bile, the green pigment made by the liver. Then it moves out of the body as waste. "When your new baby begins breathing

1 Department of Clinical Research, General Medicine, Pharmacology, Integrative Medicine, Clinical Researcher. National Institute of Medicine Sciences, Poduru Mandalam City, Andhra Pradesh State, India; 2 Preventive Medicine and Public Health, Ministry of Health, Makkah City, Kingdom of Saudi-Arabia Abstract: Hemolytic disease of the newborn (HDN), also known as Erythroblastosis fetalis , is a hemolytic condition that predominantly affects rhesus-positive fetuses and infants born to rhesus-negative mothers. The pathophysiology of HDN begins with maternal antibodies attacking fetal red blood cells following alloimmunization due to rhesus or ABO incompatibility between the maternal and fetal blood. Previously, HDN was known to cause fetal death in 1% of all pregnancies, but with the advent of immunoprophylactic therapies, the condition can be currently fairly well managed with fewer complications if diagnosed early. Diagnosis calls for extensive history taking, physical examination, sero