Medication for Drinking Addiction May Thwart Liver Disease - Medpage Today
Individuals taking medication for alcohol use disorder (AUD) were less likely to develop or experience progression of alcohol-related liver disease, a retrospective study found. Among over 9,500 patients with AUD, multivariable analysis showed that those on medical addiction therapy had a 63% lower likelihood of an alcohol-related liver disease diagnosis (adjusted odds ratio [aOR] 0.37, 95% CI 0.31-0.43), according to Jay Luther, MD, of the Massachusetts General Hospital in Boston, and colleagues. And AUD patients with cirrhosis on addiction medication had a 65% lower odds of hepatic decompensation (aOR 0.35, 95% CI 0.23-0.53), an association that "persisted" even if therapy was started after the cirrhosis diagnosis, the group reported in JAMA Network Open . "The take-home message from this study may seem obvious, but its clinical and public health importance cannot be overemphasized," wrote Lorenzo Leggio, MD, PhD, and M. Katherine Jung, PhD, both of the Nati