A committee of neonatologists, hospitalists, general pediatricians, a nurse, and breastfeeding experts worked from 2014 through 2022 to evaluate new evidence to inform the revised guidelines The American Academy of Pediatrics has revised clinical guidelines on treating infants born at least 35 weeks into pregnancy for hyperbilirubinemia. For most babies, hyperbilirubinemia leads only to jaundice, a yellow appearance to the skin and whites of the eyes. However, very rarely, it can lead to severe complications affecting the brain. The "Clinical Practice Guideline Revision: Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation," published in the September 2022 Pediatrics (published online Aug. 5) incorporates new research findings on risk-assessment and treatment. The guideline updates and replaces the 2004 AAP clinical practice guideline for the management and prevention of hyperbilirubinemia. A technical report, "Diagnosis and Managemen