Jaundice in Newborn

Abstract Objective The objective of the paper was to investigate how neonatal hematologic outcomes vary by major placental histopathology categories. Study design Placental pathology reports from 5263 subjects were coded into individual placental lesions. Infant hematologic data (complete blood count parameters ( n  = 1945), transfusions, and phototherapy) were compared by placental pathologic phenotype. Results Red blood cell transfusions were more likely with maternal vascular malperfusion (MVM; OR 9.4 [2.2, 40.8]) and chronic inflammation (1.7 [1.04, 2.7]). White blood cells were decreased with MVM (10.6 10 3 /μL vs 16.4) and elevated with acute inflammation (AI; 18.6 vs 11.9). Thrombocytopenia was associated with MVM (OR 3.7 [2.2, 5.1]) and fetal vascular malperfusion (FVM; OR 2.6 [1.5, 4.6]). Platelet transfusions were more likely with MVM (OR 8.3 [4.6, 15.0]) and FVM (OR 2.9 [1.4, 6.1]). Phototherapy was associated with MVM (OR 3.3 [2.7, 4.0]) and AI (OR 0.8 [0.6, 0.9]). Conclusi...

Hepatitis E virus (HEV) is a food- and water-borne viral illness with a worldwide prevalence of 20 million and overall mortality of 70,000 [1]. There are four genotypes of HEV, with genotypes 1 and 2 being common in developing countries as they spread via failure of basic hygiene practices and faecal contamination of drinking water, and genotypes 3 and 4 are also known to infect pigs and other mammals [2]. HEV has a mortality rate of 0.5% to 4% in immunocompetent patients, increasing to 20% in immunocompromised patients, pregnant women (mostly in the second or third trimester), and those with underlying chronic liver disease (CLD) [3]. It is also observed that the mortality associated with HEV infection is greater in developing countries like Pakistan [2]. Patients with underlying CLD may present with acute decompensation secondary to HEV infection. Among the several causes of CLD, Wilson's disease is one of the recognized causes. It i...

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When Neonatal Jaundice Is An Emergency If your baby is experiencing neonatal jaundice (yellowing of the skin), along with any of the following symptoms, call 911 immediately: High-pitched crying lasting over one hour Fever (rectal temperature over 100.4 degrees F for infants younger than 3 months) Limp or floppy body  Unresponsiveness Arched body Neonatal jaundice or hyperbilirubinemia is a common condition in newborns. It causes skin, tongue, or eye yellowing and usually occurs during the second or third day after birth. The yellowing results from too much of a naturally occurring substance called bilirubin in their blood. Jaundice often resolves on its own. Moderate cases may need treatment, such as phototherapy (light therapy). Advanced treatment may be necessary for babies with severe jaundice to prevent serious complications or health conditions. This article reviews symptoms of mild, moderate, and severe neonatal j...