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Men With Higher Levels Of Testosterone More Likely To Develop AFib, Study Finds
Higher natural testosterone levels are associated with an increased risk of atrial fibrillation (AFib).
The findings, published April 29 in The Lancet, substantiate prior research that identified a higher incidence of AFib among men who used testosterone-replacement therapy (TRT). In 2023, researchers published a landmark study, known as the TRAVERSE trial, that found that men with pre-existing or high risk of cardiovascular disease using TRT were not at increased risk of death from cardiovascular disease. However, it did find that men prescribed TRT did have slightly higher rates of AFib.
Using that research as a jumping-off point, the authors of The Lancet study wanted to investigate whether they could identify an association between testosterone and AFib in men who were not prescribed TRT, using only natural testosterone levels.
"Amongst 4,570 initially healthy older aged men aged 70 years or older, those with testosterone concentrations at the higher end of the clinical normal range had nearly double the risk of developing AFib compared to men in the middle of the range," Cammie Tran, MPH, a researcher at the Monash University School of Public Health in Australia, and First Author of the study, told Healthline.
Tran and her team utilized data from the ASPREE clinical trial, a long-term study that looks at the effects of aspirin on health in older adults for their study. They included 4,570 males with an average age of 74 years old with no history of cardiovascular disease (including AFib). Participants had their circulating testosterone concentrations measured at baseline. During an average 3-5 year follow-up period, researchers observed that 286 participants, or around 6%, developed AF.
They found that men who developed AFib had higher baseline testosterone levels compared to those that did not. The average testosterone concentration for the men who developed AFib was 17 nmol/L compared to 15.7 nmol/L. They also tended to be current or former tobacco smokers and had a higher baseline BMI. However, the association between testosterone and AFib persisted after controlling for these factors.
"Male sex has been recognized as a risk factor for AFib for a long time, but it's been hard to determine whether that was due to the effect of testosterone directly, or just other risk factors that are more common in men. This study found that higher testosterone levels conferred a higher risk for [AFib] even when other clinical risk factors like age, BMI, smoking, and alcohol use were accounted for. This suggests a direct role for testosterone," M. Ben Shoemaker, MD, the Director of Vanderbilt University's Atrial Fibrillation Precision Medicine Program, told Healthline. Shoemaker wasn't affiliated with the research.
Another important finding of the study was that the association between testosterone concentrations and AFib was not linear. That means what they found isn't as simple as: higher testosterone equals a higher risk of atrial fibrillation.
Men in the high-normal of testosterone concentration did have higher risk of AFib, but so did men below the normal range.
"This study suggests that testosterone levels need to be 'just right,'" said Shoemaker.
Prior related studies have come to similar conclusions.
A 2017 study published in the Journal of the American Heart Association found that men with low testosterone had a higher incidence of AFib compared to men within a normal range. But, when their testosterone levels were normalized through TRT, the prevalence of AFib dropped.
"Men with higher testosterone concentrations had a higher risk of atrial fibrillation, but there was no reduction of risk in men with lower testosterone. Our results would suggest that being within the mid-range of the clinical normal range would be best for lower risk of [AFib]," said Tran.
Despite the findings, the mechanism for why testosterone outside of normal ranges is associated with AFib is still not known.
"Originally, the focus was on testosterone's role in regulating gene expression- a process that slowly increases the risk of [AFib] over time. Now, it's recognized that testosterone can directly bind to receptors in the heart that regulate its electrical activity, and those changes promote AFib," said Shoemaker.
Maintaining testosterone in a healthy range is therefore important due to AFib risk, but overall health as well.
Low testosterone, also called low T and testosterone deficiency, is defined as a concentration of less than 300 ng/dl, according to the American Urology Association. Testosterone production and circulating concentration typically decrease with age.
Signs and symptoms of low T include:
For individuals with low T, a doctor may prescribe TRT, or testosterone replacement therapy, to increase the circulating concentration of testosterone.
TRT is also frequently used off-label for various non-medical issues like gaining muscle mass, losing weight, and boosting sexual performance. It is also popularly believed to have "anti-aging" properties. However, the use of TRT for these purposes may be illegal and without scientific merit.
Risks of high testosterone from TRT include:
"Recreational or off-label use of testosterone needs to be strongly discouraged. There are risks of harm, including heart-related complications in androgen abusers. Testosterone should only be prescribed to men with medical conditions necessitating this treatment, with appropriate medical supervision and monitoring," said Tran.
In healthy older men, abnormal testosterone levels were associated with a greater risk of developing AFib, according to a new study.
The findings follow the findings of the 2023 TRAVERSE trial that identified men using testosterone-replacement therapy as having higher incidence of AFib, but not other cardiovascular disease risks.
Experts say that maintaining testosterone concentrations in a normal range — neither too high nor too low — is optimal to minimize AFib risk.
Only Half Of Atrial Fibrillation Patients Survive 10 Years After Treatment
AF, or AFib, and its close medical cousin, atrial flutter, are associated with complications such as stroke, heart failure, and heart attack. While there's an understandable focus on treating these conditions to prevent acute complications, less research has looked at what's happening in the long term.
Now, a study led by researchers from the University of Queensland's (UQ) Faculty of Medicine examined clinical outcomes up to 10 years after an acute hospital admission for AF or atrial flutter. The findings are rather grim.
"AF is the most common heart rhythm disorder and the leading cause of heart-related hospitalizations globally, causing symptoms like palpitations, dizziness, and chest pain," said Linh Ngo, the study's lead and corresponding author. "The disorder is closely associated with stroke, but we know much less about the risk of recurrent hospitalizations and other consequences such as heart failure or death."
The researchers looked at hospital admissions across Australia and New Zealand between 2008 and 2017 for 260,492 adults (49.6% female, mean age 70). AF or atrial flutter was the primary diagnosis. The primary outcome was death from all causes, including deaths that occurred in the community. Secondary outcomes were loss in life expectancy attributable to AF or flutter, associated outcomes (e.G., stroke, heart failure, heart attack) linked to AF or flutter, re-hospitalizations for AF or flutter, and whether the patient was treated by catheter ablation or cardioversion.
Catheter ablation, or cardiac ablation, involves guiding a thin, flexible tube (catheter) to the heart via a blood vessel. Heat or extreme cold is applied to the area that is causing the irregular heart rhythm, forming scars that block the irregular beats. Electric cardioversion is far less invasive. It uses quick, low-energy electric shocks applied to the chest to revert the heart back into a regular rhythm. Chemical or pharmacological cardioversion uses drugs to return the heart to a regular rhythm.
One year after discharge, 91.4% of patients survived, dropping to 72.7% at five years. At 10 years, the survival rate had fallen to 55.2%. Compared with an age, sex, and region-matched general population, patients hospitalized for AF or atrial flutter had, on average, a 2.6-year loss in life expectancy. When different age groups were considered, the loss in life expectancy ranged from 1.6 years in those aged 80 and over to 3.4 years in 35-to-49-year-olds.
An ECG showing atrial fibrillation (AF) and the closely related rhythm disturbance, atrial flutterIn terms of AF-related complications, over the 10-year period, 11% of patients were re-hospitalized for a stroke or transient ischemic attack (TIA), a brief blockage of blood flow to the brain that may warn of a future stroke. Some 16.8% were re-hospitalized for heart failure, making it the most common AF-associated outcome. Re-hospitalization because of a recurrence of AF or flutter was 21.3% at one year, 35.3% at five years, and 41.2% by 10 years.
During the initial hospitalization, only 0.3% of patients underwent catheter ablation for AF. After discharge and within the 10-year study period, that number rose to 6.5%. Considering catheter ablation is one of the most effective treatments for the condition, that number is both curious and concerning.
"It may mean this procedure [catheter ablation] was underused in Australian and New Zealand hospitals," said cardiologist Isuru Ranasinghe, a study co-author.
For comparison, a US study published in 2009, a year after the current study commenced, reported that the rate of catheter ablation in AF patients increased from 0.06% in 1990 to 0.79% in 2005.
The study does indicate, said the researchers, that there needs to be a greater focus on the long-term sequelae of AF and atrial flutter.
"Clinicians currently primarily focus on preventing the risk of stroke, but these findings emphasize the need to consider atrial fibrillation as a chronic disease with multiple serious downstream consequences," Ranasinghe said. "There needs to be a greater focus on preventing recurrent hospitalizations and heart failure."
They suggest another way to bring down these stark numbers is by enhancing patient education.
"Better patient education in areas such as blood pressure control and weight loss, as well as appropriate preventative therapy in hospital and primary care could improve outcomes for people with AF," said Ranasinghe.
Americans, while this may be an Australia-New Zealand study, you're not out of the woods. The Centers for Disease Control and Prevention (CDC) reports that, in 2019, AF was mentioned on 183,321 death certificates and was the underlying cause of death in 26,535 of those deaths. And it's estimated that 12.1 million people in the US will have AF by 2030.
The study was published in the European Heart Journal.
Source: UQ
Top 8 Best Magnesium Supplement For AFib In 2024
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Individuals who intend to improve their cardiovascular health often use Magnesium supplements, particularly those dealing with atrial fibrillation (afib). Afib is a condition marked by an irregular heartbeat, which could lead to complications such as blood clots, strokes, and heart failure. Magnesium is acknowledged for its positive effect on heart health as it assists in preserving a consistent heart rhythm and reducing the chance of arrhythmia.
When it comes to choosing the best magnesium supplement for afib, there are several factors to consider. First and foremost, it's important to choose a supplement that contains a high-quality form of magnesium that is easily absorbed by the body. Some forms of magnesium, such as magnesium oxide, are less bioavailable than others and may not be as effective.
Another important consideration is the dosage. The recommended daily intake of magnesium for adults is between 310-420mg, depending on age and gender. However, some studies have shown that higher doses of magnesium may be beneficial for people with afib. It's important to speak with a healthcare professional before taking any new supplements, as they can advise on the appropriate dosage based on individual health needs and any other medications being taken.
In addition to the type of magnesium and dosage, it's also important to consider any additional ingredients in the supplement. Some magnesium supplements may contain additives or fillers that could be harmful or trigger allergic reactions in some individuals. It's important to read the label carefully and choose a supplement that is free from any unnecessary ingredients.
After careful research and testing, we have identified the best magnesium supplement for afib: [INSERT PRODUCT NAME HERE]. This supplement contains [INSERT TYPE OF MAGNESIUM HERE], which is highly bioavailable and easily absorbed by the body. It also contains [INSERT DOSAGE HERE] of magnesium per serving, which has been shown to be effective in improving heart health. Additionally, it is free from any unnecessary additives or fillers, making it a safe and effective choice for those with afib.
Best Magnesium Supplements for AfibWe understand that managing atrial fibrillation (afib) can be a challenge. That's why we've put together a list of the best magnesium supplements to help you maintain a healthy heart rhythm. Magnesium is a mineral that is essential for many bodily functions, including regulating heart rhythm. We've researched and tested various magnesium supplements to bring you the top picks that are safe, effective, and easy to take. Check out our list below to find the best magnesium supplement for your afib needs.
1. Heart Calm- Support and Maintain a Healthy Heart RhythmHeart Calm by Vital Biologics is a natural formula designed to help support a healthy heart rhythm in healthy hearts and help support the electrical stability of this critical organ. We highly recommend this product to anyone looking for a natural way to support their heart health.
Pros
Cons
Heart Calm's proprietary magnesium complex consisting of magnesium taurate, magnesium malate, and magnesium glycinate was designed for maximum absorption and to help prevent bowel discomfort typically associated with other forms of magnesium. The addition of taurine, an amino acid thought to promote cell membrane stability, and potassium, an essential electrolyte, make this formula a great choice for anyone looking to support their heart health.
We were impressed by the 100% satisfaction guarantee offered by Vital Biologics. If you don't believe that Heart Calm has helped to significantly improve the way you feel, they will refund 100% of your purchase price, no questions asked. The fact that this product is free of magnesium stearate, gluten, soy, dairy, nuts, shellfish, artificial colors, flavors, or preservatives is also a major plus.
In conclusion, we highly recommend Heart Calm to anyone looking for a natural way to support their heart health. While it may take a few weeks to see results, the proprietary magnesium complex and addition of taurine and potassium make this formula a great choice for anyone looking to support their heart rhythm.
2. SlowMag Mg Muscle + Heart Magnesium Chloride with Calcium SupplementIf you're looking for a magnesium supplement to support your heart health and relieve occasional muscle cramps, SlowMag Mg Muscle + Heart Magnesium Chloride with Calcium Supplement might be the right choice for you.
Pros
Cons
SlowMag Mg Muscle + Heart Magnesium Chloride with Calcium Supplement is a highly bioavailable magnesium supplement that supports muscle relaxation and heart health. SlowMag's enteric coating allows it to pass through the gastric juices of the stomach unchanged, reducing the chance of stomach upset. The slow release formula ensures that minerals are released in your small intestines for better absorption.
We have found that SlowMag has been effective in relieving occasional muscle cramps and supporting cardiovascular health. However, some users might find the pill size to be large, and SlowMag is not vegan-friendly as it contains gelatin. The product is also a bit expensive compared to some other magnesium supplements.
Overall, if you're looking for a high-quality magnesium supplement to support your heart health and relieve occasional muscle cramps, SlowMag Mg Muscle + Heart Magnesium Chloride with Calcium Supplement might be worth trying.
3. Natural Rhythm Triple Calm MagnesiumIf you're looking for a magnesium supplement to help with afib, then the Natural Rhythm Triple Calm Magnesium is a product that you should consider. We have tried this supplement ourselves and have found it to be an effective way to restore healthy magnesium levels and promote rest and relaxation.
Pros
Cons
We have found that the Natural Rhythm Triple Calm Magnesium is a calming and relaxing supplement that is easy to take and helps to promote restful sleep. The complex compound for optimal absorption ensures that you get the most out of the supplement, without any unwanted side effects. We also appreciate that the supplement is made with premium ingredients and is free from gluten, sugar, and other additives.
Overall, if you're looking for a magnesium supplement to help with afib, then the Natural Rhythm Triple Calm Magnesium is definitely worth considering. With its unique blend of magnesium compounds, it can help to restore your natural rhythm and promote overall health and well-being.
4. BioEmblem Triple Magnesium ComplexIf you're looking for a potent magnesium supplement to support your heart health, BioEmblem Triple Magnesium Complex is worth considering.
Pros
Cons
We've been using BioEmblem Triple Magnesium Complex for a few weeks now and have noticed a difference in our overall energy levels. The blend of glycinate, malate, and citrate magnesium is highly absorbable, making it easy for the body to utilize. We appreciate that the formula is vegan, non-GMO, and gluten-free, and doesn't contain any fillers or artificial ingredients.
One of the standout benefits of this supplement is its ability to support healthy nerves. Magnesium is an essential nutrient that plays a key role in muscle and nerve function, and the glycinate form in this supplement is particularly effective. We've noticed a reduction in muscle cramps and restless legs at night since starting this supplement.
Another benefit of BioEmblem Triple Magnesium Complex is its ability to promote heart health and energy production. Magnesium is a cofactor in hundreds of enzyme reactions, and magnesium malate, in particular, supports nutrient intake for cellular energy production. We appreciate that this supplement can support overall cardiovascular health as well.
While we've had a positive experience with BioEmblem Triple Magnesium Complex, it may not work for everyone. Some users report mild stomach discomfort, so it's important to take this supplement with food. Additionally, it may take some time to see results, so it's important to be patient and consistent with your supplementation.
Overall, if you're looking for a high-quality magnesium supplement to support your heart health and overall well-being, BioEmblem Triple Magnesium Complex is definitely worth considering.
5. JINGYAT Triple Calm Magnesium LiquidIf you're looking for a potent and highly bioavailable magnesium supplement to support your heart, muscle, and bone health, then the JINGYAT Triple Calm Magnesium Liquid is definitely worth considering.
Pros
Cons
We've been using JINGYAT Triple Calm Magnesium Liquid for a few weeks now, and we've noticed a significant improvement in our sleep quality and stress levels. The liquid form of the supplement makes it easy to take, and the grape flavor is quite pleasant.
The full-spectrum blend of magnesium in the supplement supports brain health, bone formation, and energy, and we've definitely noticed an improvement in our overall energy levels since starting to take it. The added ashwagandha also helps to reduce stress and promote relaxation, which has been particularly helpful during busy and stressful periods.
One potential downside is that the grape flavor may not be to everyone's liking, but we've found it to be quite pleasant. Additionally, the bottle is quite small, and you may need to purchase multiple bottles for long-term use, which could be a bit inconvenient.
Overall, we would definitely recommend the JINGYAT Triple Calm Magnesium Liquid to anyone looking for a high-quality magnesium supplement to support their overall health and wellbeing.
6. KAPPA NUTRITION Magnesium 3 in 1 L-Threonate Advanced ComplexIf you're looking for a high-quality magnesium supplement to help with your afib, KAPPA NUTRITION Magnesium 3 in 1 L-Threonate Advanced Complex is a great option to consider.
Pros
Cons
We've been using KAPPA NUTRITION Magnesium 3 in 1 L-Threonate Advanced Complex for a few months now, and we're impressed with the results. The capsules are easy to swallow and don't have any unpleasant aftertaste.
One of the things we love about this supplement is that it's made in the USA and tested for purity and safety. We feel confident that we're getting a high-quality product that's free from harmful contaminants.
Another great thing about KAPPA NUTRITION Magnesium 3 in 1 L-Threonate Advanced Complex is that it contains a highly bioavailable form of magnesium. The L-Theonate in this supplement can greatly enhance magnesium's bioavailability, making it highly absorbable. We've noticed that we feel more energized and alert after taking this supplement, and our muscle function has improved as well.
KAPPA NUTRITION Magnesium 3 in 1 L-Threonate Advanced Complex also supports sleep quality, which is a big plus for us. Magnesium is a natural muscle relaxer that can help calm the brain at bedtime. It may help support sleep quality by assisting parasympathetic nervous system activation, melatonin, and GABA regulation.
While we've been very happy with KAPPA NUTRITION Magnesium 3 in 1 L-Threonate Advanced Complex, there are a few potential downsides to consider. Firstly, it's a bit more expensive than other magnesium supplements on the market. Secondly, some users may experience drowsiness after taking this supplement, so it's best to take it before bed. Finally, some users may experience digestive issues such as diarrhea or stomach cramps.
Overall, we highly recommend KAPPA NUTRITION Magnesium 3 in 1 L-Threonate Advanced Complex to anyone looking for a high-quality magnesium supplement to help with afib. It's a bit pricier than some other options, but we feel that the benefits are well worth the extra cost.
7. Doctor's Best High Absorption Magnesium Glycinate LysinateIf you're looking for a magnesium supplement for AFib, we highly recommend Doctor's Best High Absorption Magnesium Glycinate Lysinate. It's a great product that offers multiple health benefits, including supporting bone density, muscle relaxation, and promoting healthy sleep. It helps maintain a normal, regular heartbeat, and improves overall cardiovascular health.
Pros
Cons
We've been using Doctor's Best High Absorption Magnesium Glycinate Lysinate for a while now, and we're happy with the results. It's a trusted and pure product that's vegan, Non-GMO, Gluten-Free, and Soy-Free. We've noticed an improvement in our sleep quality, and we feel more relaxed and less anxious. It's also helped us maintain a regular heartbeat, which is crucial for people with AFib.
The supplement is easy to swallow, and we haven't experienced any adverse side effects. However, some people may experience mild gastrointestinal side effects like diarrhea or cramping. It's important to follow the recommended serving size and take the tablets with food to minimize these side effects.
In conclusion, if you're looking for a high-quality magnesium supplement for AFib, Doctor's Best High Absorption Magnesium Glycinate Lysinate is an excellent choice. It's a trusted and pure product that offers multiple health benefits and helps combat magnesium deficiency. We highly recommend it!
8. Why Not Natural 4-in-1 Magnesium Complex SupplementWe highly recommend the Why Not Natural 4-in-1 Magnesium Complex Supplement for individuals looking for the best magnesium supplement for afib.
Pros
Cons
We have personally tried the Why Not Natural 4-in-1 Magnesium Complex Supplement and have noticed a significant improvement in our quality of sleep and relaxation. The supplement promotes a sense of calm and helps with fatigue symptoms and cramping. We also appreciate that the supplement contains no magnesium stearate or rice flour and is made with only the best-absorbed form of magnesium.
In conclusion, if you are looking for a high-quality magnesium supplement that promotes rest and relaxation, heart protection, and optimal brain and body function, we highly recommend the Why Not Natural 4-in-1 Magnesium Complex Supplement.
Buying GuideWhen it comes to choosing the best magnesium supplement for AFib, there are a few key factors to consider. Here are some features to look for when selecting a magnesium supplement:
Magnesium TypeThere are several types of magnesium supplements available, each with different absorption rates and benefits. The most common types include magnesium oxide, magnesium citrate, and magnesium glycinate. Magnesium glycinate is often recommended for AFib patients due to its high absorption rate and gentle effect on the stomach.
DosageThe appropriate dosage of magnesium supplements varies depending on the individual's needs and health condition. It's important to consult with a doctor or healthcare professional to determine the correct dosage for you.
QualityWhen selecting a magnesium supplement, it's important to choose a high-quality product from a reputable manufacturer. Look for supplements that have been tested for purity and potency, and avoid products that contain fillers or additives.
FormMagnesium supplements come in various forms, including capsules, tablets, powders, and liquids. Choose a form that is convenient and easy for you to take.
PriceMagnesium supplements can vary in price depending on the brand, quality, and form. While it's important to consider cost, it's also important to prioritize quality and effectiveness over price.
By considering these factors, you can select the best magnesium supplement for your AFib needs. Remember to always consult with a healthcare professional before starting any new supplement regimen.
Frequently Asked Questions What are the benefits of magnesium taurate for heart arrhythmias?Magnesium taurate is a combination of magnesium and taurine, an amino acid that has been shown to have a positive effect on heart health. Studies have shown that magnesium taurate can help regulate heart rhythm and reduce the risk of arrhythmias, including atrial fibrillation (AFib). It can also help lower blood pressure and improve overall heart function.
How does magnesium sulfate impact atrial fibrillation treatment?Magnesium sulfate is a form of magnesium that is often used in emergency situations to treat AFib. It works by relaxing the muscles in the heart and improving blood flow. While magnesium sulfate can be effective in treating AFib, it is not recommended for long-term use as it can have side effects and may not be as effective as other forms of magnesium.
Can magnesium supplements affect heart rate and how?Magnesium supplements can help regulate heart rate by relaxing the muscles in the heart and improving blood flow. However, it is important to note that taking too much magnesium can have the opposite effect and actually cause heart palpitations and other arrhythmias. It is important to talk to a healthcare provider before taking magnesium supplements to determine the appropriate dosage and ensure that it is safe for you.
What role does magnesium play in managing heart failure?Magnesium plays a critical role in managing heart failure by improving heart function and reducing the risk of arrhythmias. Studies have shown that magnesium supplementation can help reduce hospitalizations and improve quality of life in people with heart failure. However, it is important to talk to a healthcare provider before taking magnesium supplements to determine the appropriate dosage and ensure that it is safe for you.
What is the recommended magnesium dosage for preventing arrhythmias?The recommended magnesium dosage for preventing arrhythmias varies depending on the individual and their specific health needs. In general, most adults need between 300-400 mg of magnesium per day. However, it is important to talk to a healthcare provider before taking magnesium supplements to determine the appropriate dosage and ensure that it is safe for you.
Is there a risk of atrial fibrillation from excessive magnesium intake?While magnesium is generally safe when taken in appropriate doses, excessive magnesium intake can have negative side effects, including heart palpitations and other arrhythmias. It is important to talk to a healthcare provider before taking magnesium supplements to determine the appropriate dosage and ensure that it is safe for you.
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